El laboratorio de la Dra. Celina Kleer en el Departamento de Patologia y Rogel Cancer Center de la Universidad de Michigan tiene una posicion para fellow posdoctoral por 3-5 años. El Kleer lab investiga mecanismos de invasion y metastasis del cancer de mama con estudios en biología molecular, nuevos modelos de ratones, y tejidos humanos.
Mas información sobre el lab está en el website:
Publicaciones representativas recientes del Kleer lab.
Gonzalez ME, Naimo GD, Anwar T, Paoli A, Tekula SR, Kim S, Medhora N, Leflein SA, Itkin J, Trievel R, Kidwell K., Chen YC, Mauro L, Yoon E, Ando S, and Kleer CG. EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression. iScience, in press 2022.
Djomehri SI, Gonzalez ME, da Veiga Leprevost F, Tekula SR, Chang HY, White MJ, Cimino-Mathews A, Burman B, Basrur V, Argani P, Nesvizhskii AI*, Kleer CG*. Quantitative proteomic landscape of metaplastic breast carcinoma pathological subtypes and their relationship to triple-negative tumors. Nat Commun 11(1):1723, 2020. PMCID: PMC7138853. (* denotes co-senior authors). This paper was highlighted in the Nature Communications Collection on Biological Mass Spectrometry.
Anwar T, Arellano-Garcia C, Ropa J, Chen YC, Kim HS, Yoon E, Grigsby S, Basrur V, Nesvizhskii AI, Muntean A, Gonzalez ME, Kidwell KM, Nikolovska-Coleska Z, Kleer CG. p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis. Nat Commun 9(1):2801, 2018. PMCID: PMC6051995. This paper was highlighted in the Nature Communications Collection "Breast Cancer Awareness Month"
Martin EE, Huang W, Anwar T, Arellano-Garcia C, Burman B, Guan J-L, Gonzalez ME, Kleer CG. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene 2017;36(16):2275-85. PMID: 27819674
